Alaclov Tablet 500 mg (1 Strip=10 Pieces)
Original price was: 402.70৳ .382.56৳ Current price is: 382.56৳ .
Indications
Varicella zoster virus (VZV) infections: Alaclov is indicated for the treatment of herpes zoster (shingles) and ophthalmic zoster in immunocompetent adults. It also is indicated for the treatment of herpes zoster in adult patients with mild or moderate immunosuppression. Herpes simplex virus (HSV) infections.
Treatment and suppression of HSV infections of the skin and mucous membranes including:
- Treatment of first-episode of genital herpes in immunocompetent adults and adolescents and in Immunocompromised adults
- treatment of recurrences of genital herpes in immunocompetent adults and adolescents, and in immunocompromised adults
- suppression of recurrent genital herpes in immunocompetent adults and adolescents and in immunocompromised adults
- Treatment and suppression of recurrent ocular HSV infections.
- Cytomegalovirus (CMV) infections: Alaclov is indicated for the prophylaxis of CMV infection and disease following solid organ transplantation in adults and adolescents.
Pharmacology
Dosage & Administration
Varicella zoster virus (VZV) infections- herpes zoster: Patients should be advised to start treatment as soon as possible after a diagnosis of herpes zoster. There are no data on treatment started more than 72 hours after onset of the zoster rash. Immunocompetent Adults: The dose in immunocompetent patients is Valacyclovir 1000mg (1 Valacyclovir 1000mg tablet) three times daily for 7 days (3000mg total daily dose).
Immunocompromised Adults: The dose in immunocompromised patients is Valacyclovir 1000mg (1 Valacyclovir 1000mg tablet) 3 times daily for at least 7 days (3000mg total daily dose) and for 2 days following crusting of lesions. In immunocompromised patients, antiviral treatment is suggested for patients presenting within one week of vesicle formation or at any time before full crusting of lesions.
Treatment of herpes simplex virus (HSV) infections in adults and adolescents (>12 years): Immunocompetent Adults and Adolescents (³12 years): The dose is Valacyclovir 500mg (1 Valacyclovir 500mg tablet) to be taken twice daily (1000mg total daily dose). This dose should be reduced according to creatinine clearance. For recurrent episodes, treatment should be for 3 to 5 days. For initial episodes, which can be more severe, treatment may have to be extended to 10 days. Dosing should begin as early as possible. For recurrent episodes of herpes simplex, this should ideally be during the prodromal period or immediately upon appearance of the first signs or symptoms. Valacyclovir can prevent lesion development when taken at the first signs and symptoms of an HSV recurrence.
Herpes labialis: For herpes labialis (cold sores), Valacyclovir 2000mg (2 Valacyclovir 1000mg tablet) twice daily for one day is effective treatment in adults and adolescents. The second dose should be taken about 12 h (no sooner than 6 h) after the first dose. This dose should be reduced according to creatinine clearance. When using this dosing regimen, treatment should not exceed one day, since this has been shown not to provide additional clinical benefit. Therapy should be initiated at the earliest symptom of a cold sore (e.g. tingling, itching or burning).
Immunocompromised Adults: The dosage is Valacyclovir 1000mg (1 Valacyclovir 1000mg tablet) twice daily for at least 5 days, following assessment of the severity of the clinical condition and immunological status of the patient. For initial episodes, which can be more severe, treatment may have to be extended to ten days. Dosing should begin as early as possible. This dose should be reduced according to creatinine clearance. For maximum clinical benefit, the treatment should be started within 48 hours. A strict monitoring of the evolution of lesions is advised.Suppression of recurrences of herpes simplex virus (HSV) infections in adults and adolescents (12 years)
Immunocompetent Adults and Adolescents (12 years): The dose is Valacyclovir 500mg (1 Valacyclovir 500mg tablet) to be taken once daily. Some patients with very frequent recurrences (10/year in absence of therapy) may gain additional benefit from the daily dose of Valacyclovir 500mg (1 Valacyclovir 500mg tablet) being taken as a divided dose (250mg twice daily). Treatment should be re-evaluated after 6 to 12 months of therapy.
Immunocompromised Adults: The dose is Valacyclovir 500mg (1 Valacyclovir 500mg tablet) twice daily. Treatment should be re-evaluated after 6 to 12 months of therapy. Prophylaxis of cytomegalovirus (CMV) infection and disease in adults and adolescents (12 years) The dosage of Valacyclovir is 2000mg (2 Valacyclovir 1000 mg tablet) four times a day, to be initiated as early as possible post-transplant. This dose should be reduced according to creatinine clearance.The duration of treatment will usually be 90 days, but may need to be extended in high-risk patients.
Interaction
Contraindications
Side Effects
Pregnancy & Lactation
Precautions & Warnings
Hydration status: Care should be taken to ensure adequate fluid intake in patients who are at risk of dehydration, particularly the elderly.
Use in patients with renal impairment and in elderly patients: Aciclovir is eliminated by renal clearance; therefore the dose of Alaclov must be reduced in patients with renal impairment. Elderly patients are likely to have reduced renal function and therefore the need for dose reduction must be considered in this group of patients. Both elderly patients and patients with renal impairment are at increased risk of developing neurological side-effects and should be closely monitored for evidence of these effects. In the reported cases, these reactions were generally reversible on discontinuation of treatment.
Use of higher dose of Alaclov in hepatic impairment and liver transplantation: There are no data available on the use of higher doses of Alaclov (4000mg or more per day) in patients with liver disease. Specific studies of Alaclov have not been conducted in liver transplantation, and hence caution should be exercised when administering daily doses greater than 4000mg to these patients.
Use for zoster treatment: Clinical response should be closely monitored, particularly in immunocompromised patients. Consideration should be given to intravenous antiviral therapy when response to oral therapy is considered insufficient. Patients with complicated herpes zoster, i.e. those with visceral involvement, disseminated zoster, motor neuropathies, encephalitis and cerebrovascular complications should be treated with intravenous antiviral therapy. Moreover, immunocom-promised patients with ophthalmic zoster or those with a high risk for disease dissemination and visceral organ involvement should be treated with intravenous antiviral therapy.
Transmission of genital herpes: Patients should be advised to avoid intercourse when symptoms are present even if treatment with an antiviral has been initiated.
Use of ocular HSV infections: Clinical response should be closely monitored in these patients. Consideration should be given to intravenous antiviral therapy when response to oral therapy is unlikely to be sufficient.
Use in CMV infections: Data on the efficacy of Alaclov from transplant patients at high risk of CMV disease indicate that Alaclov should only be used in these patients when safety concerns preclude the use of valganciclovir or ganciclovir. High dose Alaclov as required for CMV prophylaxis may result in more frequent adverse events than observed with lower doses administered for other indications. Patients should be closely monitored for changes in renal function, and doses adjusted accordingly.
Overdose Effects
Therapeutic Class
Storage Conditions
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