Azelaic acid INN 0.2gm/gm (20%): Cream Azelaic acid has been shown to possess antimicrobial activity against propionibacterium acnes and staphylococcus epidermidis.
Mode of action: The antimicrobial action of azelaic acid may be attributable to inhibition of microbial cellular protein synthesis. A normalization of keratinization leading to an
anticomedonal effect of azelaic acid may also contribute to its clinical activity.
Ind: Azelaic acid cream is indicated for the topical treatment of mild-to-moderate infl ammatory acne vulgaris.
C/I: Hypersensitivity to any of its components.
S/E: Local skin irritation ( e.g erythema, scaling, itching or burning) occurs in occasional cases, usually at the start of treament. However, in the majority of cases the irritation is mild and regresses as treatment continues.
Precaution: For external use only. If azelaic acid comes in contact with the eyes they should immediately be thoroughly rinsed with copius amounts of water. The patients should consult a physician if eye irritation persists.
Pregnancy & lactation: This drug should be used during pregnancy only if clearly needed. Caution should be exercised when azelaic acid is administered to a nursing mother.
Dosage & admin: After the skin is thoroughly washed and patted dry, a thin film of azelaic acid should be gently but thoroughly massaged into the affected areas twice daily, in the morning and evening. The hands should be washed following application.
Children: Safety and effectiveness in pediatric patients under 12 years of age have not been established.
5gm tube: 40.15 MRP