An appropriate preparation of parenteral nutrition. Each 1 OOml of solution contains dextrose anhydrous USP lOgm (i.e 10%) & sodium chloride BP 0.225gm (i.e 0.225%): i.v
injection for infusion.
Mode of action: Dextrose solution helps in restoring blood glucose levels & provides caloreis. It may aid in minimizing liver glycogen depletion & exerts a protein sparing action.
Sodium chloride in water dissociates into sodium (Na+) and chloride (Cl-) ions. Sodium is the principal cation of the extracellular fluid & plays important role in fluid therapy & electrolyte disturbances. Chloride has an integral role in buffering action when oxygen & carbon dioxide exchange occurs in the red blood cells. The distribution & excretion of sodium & chloride are largely under the control of the kidney which maintains a balance between intake & output.
Ind: APN injection is indicated for parenteral replenishment of fluid, minimal carbohydrate calories & sodium chloride as required by the clinical condition of the patient, specially children.
C/I: None known.
S/E: Thrombosis of the chosen vein is always a possibility with i.v infusion, if infusion is protracted, then another vein should be selected after 12 to 24 hours.
Precaution: Caution should be exercised in diabetic patient.
Pregnancy & lactation: It is not known whether dextrose or sodium chloride can cause fetal harm wben administered to a pregnant or lactating woman. Dextrose or sodium chloride should be given to a pregnant woman only if clearly needed.
Dosage & admin: APN injection can be administered i. v at the rate of 30 to 60 drops per minute or as directed by the physician.
500ml bot: 65.25 MRP