Clonidinedrochloride USP 0.1 mg and 0.3mg/tablet.

Mode of action: Clonidine hydrochloride stimulates alpha-adrenoreceptors in the barm stem. This action results in reduced sympathetic outflow from the central nervous system and in decreased in peripheral resistance, renal vascular resistance, heart rate, and blood pressure.
Ind: Clonidine is indicated in multiple uses: i. Hypertensive urgencies, resistant hypertension and atrial fibrillation; ii. For the treatment of attention deficit hyperactivity disorder- ADHD (is characterized by behavioral and learning disorder); iii. Autism, (a development disturbance, characterized by an abnormal or impaired development in social communications and interaction skills and significantly restricted range of activities and interests); iv. Tourette's syndrome, (a neurological disorder in which the major symptom is tics which are sudden, brief, involuntary movements or sounds); v. For growth retardation, (clonidine has been reported to be a stimulant of growth hormone release, presumably as a result of central alpha adrenergic stimulation); vi. Menopausal hot flash; and vii. Opioid detoxification.

C/I: Any hypersensitivity to clonidine.

S/E: Most adverse effects are mild and tend to diminish with continued therapy. The most frequent adverse effects (which appear to be dose related) are dry mouth, drowsiness, dizziness, constipation and sedation. Less frequent adverse effects are headache, with-drawal syndrome, tachycardia, bradycardia, depression, nervousness, anxiety, restlessness, urticaria, urine retention etc.

Pregnancy & lactation: No adequate, well con¬trolled stuides have been conducted in pregnant women. So, it should be used during pregnancy only if clearly needed. As clonidine is excreted in human milk, caution should be exercised when it is administered to nursing mother.
Dosage & admin: i. Hypertensive urgencies, O.lmg twice daily to manage the hypertensive crisis than tailing off the therapy; resistant hypertension, O.lmg twice daily; atrial fibrillation, 0.075mg once or twice daily alone or with digoxin; ii. For the treatment of attention deficit hyperactivity disorder (ADHD), 5mcg/kg/day. iii. Autism, 0.15mg to 0.2mg/day. iv. Tourette's syndrome, 150- 200mcg/day. v. For growth retardation, 37.5- 150mcg/m2/day. vi. Menopausal hot flash, O.lmg to 0.4mg daily for up to 2 weeks.
Drug inter: Clonidine may potentiate CNS depressive effect of alcohol, barbiturates or other sedative drugs. Hypotensive effect may be reduced if a patient receives clonidine and tricyclic anti-depressant, where increased dose of clonidine is required. Due to a potential for additive effects (such as bradycarida & A.V block) caution is warranted in patients receiving clonidine concomitantly with agents (e.g digitalis, calcium channel blockers & ? -blockers) known to affect sinus node function or A.V nodal conduction.

0.lmg x 50's pack: 301.00 MRP