Flurbiprofen BP 50mg/tablet (film-coated).
Flurbiprofen is a potent non-steroidal antiinflammatory drug with antipyretic and analgesic activity.
Mode of action: Flurbiprofen is a cyclooxygenase inhibitor. It inhibits prostaglandin and thromboxane biosynthesis. It inhibits vasodilatation and also prevents the sensitization of pain fibers by prostaglandins.
Ind: Pain and inflammation in rheumatic disease and other musculoskeletal disorders such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, frozen shoulder, low back pain, sprains & strains; mild to moderate pain including dysmenorrhoea; migraine; post-operative analgesia, dental pain; relief of sore throat.
C/I: Active peptic ulceration or recent gastrointestinal hemorrhage, ulcerative colitis.
Bronchospasm and other hypersensitivity-type reactions with aspirin and other non-steroidal agents. Relative contraindications are anticoagulant therapy, diuretic therapy and patients with history of heart failure/hypertension and nonallergic asthma. Patients with a prior hypersensitivity to flurbiprofen or any other ingredient in the formulation.
S/E: The most important side effects are peptic ulceration, hemorrhage and perforation. Gastrointestinal adverse effects includedyspepsia, nausea, vomiting, constipation and
diarrhea. There may be peripheral edema due to salt and water retention. Some neurological reactions such as dizziness, tinnitus, deafness and blurred vision have been reported which have disappeared on withdrawal of the drug.
Prec autions: Flurbiprofen has not been exten sively studied in children. If is not recommended for children under 12 years of age.
Pregnancy & lactation: The safety of flurbiprofen during pregnancy has not been established. Breast feeding is not contraindication but sa.fety is not declared.
Dosage: 150-200mg daily in divided doses, increased in acute conditions to 300mg daily. In dysmenorrhoea, initially 1 OOmg, then 50- 1 OOmg every 4-6 hours; maximum 300mg daily. Missed dose: Take the missed dose as soon as remembered. However, if it is almost time for the next dose, skip the missed dose and continue regular dosing schedule. Do not take a double dose to make up for a missed one. Drug inter: Care should be taken in patients treated with any of the following drugs as interactions have been reported in some patientsantihypertensives, diuretics, cardiac glycosides, lithium, methotrexate etc.
30's pack: 150.60 MRP