Azithromycin 500mg/tablet
500mg x 9s pack: 499.50 MRP

Indications

Azyth 500 is shown for diseases (caused by helpless living beings) in lower respiratory tract contaminations counting bronchitis and pneumonia, in upper respiratory tract contaminations counting sinusitis and pharyngitis/tonsillitis, in otitis media, and in the skin and delicate tissue diseases. In sexually transmitted illnesses in men and ladies, Azithromycin is demonstrated within the treatment of non-gonococcal urethritis and cervicitis due to Chlamydia trachomatis.

Pharmacology

Azithromycin is acid-stable and can subsequently be taken orally with no requirement of security from gastric acids. It is promptly ingested; its retention is more noteworthy on a purge stomach. The time to top concentration in grown-ups is 2.1 to 3.2 hours for verbal measurement shapes. Due to the tall concentration in phagocytes, azithromycin is effectively transported to the location of the disease. Amid dynamic phagocytosis, huge concentrations of azithromycin are discharged. The concentration of azithromycin within the tissues can be over 50 times higher than in plasma. This is often due to particle catching and tall lipid solubility.

Azithromycin is acid-stable and can subsequently be taken orally with no requirement of assurance from gastric acids. It is promptly retained; its retention is more noteworthy on a purge stomach. Time to crest concentration in grown-ups is 2.1 to 3.2 hours for verbal measurement shapes. Due to the tall concentration in phagocytes, azithromycin is effectively transported to the location of contamination. Amid dynamic phagocytosis, expansive concentrations of azithromycin are discharged. The concentration of azithromycin within the tissues can be over 50 times higher than in plasma. Usually due to particle catching and the tall lipid solubility.

Microbiology: Azithromycin acts by binding to the 50S ribosomal subunit of susceptible microorganisms and, thus, interfering with microbial protein synthesis. Nucleic acid synthesis is not affected. Azithromycin has been shown to be active against most isolates of the following microorganisms, both in vitro and in clinical infections:

• Aerobic and facultative gram-positive microorganisms: Staphylococcus aureus, Streptococcus agalactiae, Streptococcus pneumonia, Streptococcus pyogenes
• Aerobic and facultative gram-negative microorganisms: Haemophilus ducreyi, Haemophilus influenzae, Moraxella catarrhalis, Neisseria gonorrhoeae
• Other microorganisms: Chlamydia pneumoniae, Chlamydia trachomatis, Mycoplasma pneumonia, and Beta-lactamase production should have no effect on azithromycin activity.
• Aerobic and facultative gram-positive microorganisms: Streptococci (Groups C,F, G), Viridans group streptococci
• Aerobic and facultative gram-negative microorganisms: Bordetella pertussis, Legionella pneumophila
• Anaerobic microorganisms: Peptostreptococcus species, Prevotella bivia.

Dosage & Administration

Oral-
Adult:

• 500 mg once daily orally for 3 days or 500 mg once on day 1, then 250 mg once on days 2-5 for 4 days.
• For sexually transmitted diseases caused by Chlamydia trachomatis in adults, the dose is 1 gm given as a single dose or 500 mg once on day 1, followed by 250 mg once daily for the next 2 days may also be given.

Children:

• 10 mg/kg body weight once daily for 3 days for the child over 6 months
• 200 mg (1 teaspoonful) for 3 days if body weight is 15-25 kg
• 300 mg (1½ teaspoonfuls) for 3 days if bodyweight is 26-35 kg; 400 mg (2 teaspoonfuls) for 3 days if bodyweight is 36-45 kg.
• In typhoid fever, 500 mg (2½ teaspoonfuls) once daily for 7-10 days is given.

Azithromycin Injection (For IV Infusion only): The recommended dose of Azithromycin for injection for the treatment of adult patients with community-acquired pneumonia due to the indicated organisms is:

• 500 mg as a single daily dose by the intravenous route for at least two days. Intravenous therapy should be followed by Azithromycin by the oral route at a single, daily dose of 500 mg, administered as two 250-mg tablets to complete a 7 to 10-day course of therapy. The timing of the switch to oral therapy should be done at the discretion of the physician and in accordance with the clinical response.
• The recommended dose of Azithromycin for the treatment of adult patients with pelvic inflammatory disease due to the indicated organisms is 500 mg as a single daily dose by the intravenous route for one or two days. Intravenous therapy should be followed by Azithromycin by the oral route at a single, daily dose of 250 mg to complete a 7-day course of therapy. The timing of the switch to oral therapy should be done at the discretion of the physician and in accordance with the clinical response. If anaerobic microorganisms are suspected of contributing to the infection, an antimicrobial agent with anaerobic activity should be administered in combination with Azithromycin.
• The safety and effectiveness of azithromycin for injection in children or adolescents under 16 years have not been established.

Interaction

Azithromycin assimilation is decreased in the nearness of nourishment and stomach-settling agent. In patients accepting ergot alkaloids, Azithromycin ought to be maintained at a strategic distance from since the plausibility of ergotism coming about from the interaction of Azithromycin with the cytochrome P-450 framework. As macrolides increment the plasma concentration of digoxin and cyclosporin, caution ought to be worked out whereas co-administration. There has been no medicating intuition between Azithromycin and Warfarin, Theophylline, Carbamazepine, Methylprednisolone, or Cimetidine.

Contraindications

Patients who are hypersensitive to Azyth 500 or any other macrolide antibiotic should avoid taking it. Ergot derivatives and azithromycin should not be taken together. Patients with hepatic disorders should avoid Azyth 500.

Side Effects

Azyth 500 is a well-tolerated antibiotic with few adverse effects. Nausea, vomiting, abdominal discomfort (pain/cramps), flatulence, diarrhea, headache, dizziness, and skin rashes are among the side effects, which are reversible as the medication is stopped.

Pregnancy & Lactation

The pregnancy Category of Azithromycin is B. Creature generation ponders have illustrated that Azithromycin has no proof of hurt to the baby. There are no satisfactory and well-controlled things about pregnant ladies. Since creature generation considers is not continuously prescient of human reaction, Azithromycin ought to be utilized amid pregnancy as it were in the event that satisfactory choices are not accessible. It isn't known whether Azithromycin is discharged in the breast drain. So, caution ought to be worked out when Azithromycin is managed by nursing ladies.

Precautions & Warnings

Observation for signs of superinfection with non-susceptible organisms, especially fungus, is suggested with any antibiotic. In patients with renal impairment, there is no need to alter the dose.

Therapeutic Class

Macrolides.

Storage Conditions

Keep the temperature below 30°C and away from light and moisture. Keep out of children's reach.