Rimstar 4-FDC presents- Rifampicin 150mg +
Isoniazid 7 5mg + Pyrazinamide 400mg +
Ethambutol 275mg/tablet.
Ind: Rifampicin, isoniazid, pyrazinamide and
ethambutol are major drugs in the management
of tuberculosis and in certain opportunist
mycobacterial infections. Rifampicin is also
effective in the cases resistant to other antituberculous
agents.
C/I: In known or suspected hypersensitivity to
rifampicin and/or to isoniazid, pyrazinamide and
ethambutol and/or to any of the excipients,
including, a history of drug induced hepatitis,
acute liver diseases, peripheral neuritis and optic
neuritis.
S/E: Please see under individual preparation.
Precautions: Caution is advised in patients with
impaired renal, liver and visual function, diabetes
mellitus, gout.
Pregnancy: Should not be given during
pregnancy unless the potential benefit justifies
the potential risk to the foetus.
Dosage: The total dosage requirement of
rifampicin is 10 (8 to 12) mg/kg/day, of
isoniazid 5 (4 to 6) mg/kg/day, of pyrazinamide
25 (20 to 30) mg/kg/day and of ethambutol 15
(15-20) mg/kg/day.
Calculating the daily dosage as above, a treatment
schedule has been prepared as below:
New patients:
Body weight < 50kg, initial 2 months- Rimstar
4-FDC 3 tablets at a time daily; next 4
months- continuation dose Rifampicin 450mg
+ Isoniazid 300mg (or Rimactazid-450 one
tablet) daily.
QIMP-17 (297)
Body weight > 50kg, initial 2 months- Rimstar
4-FDC 4 tablets at a time daily; next 4
months- continuation dose Rifampicin 600mg
+ Isoniazid 300mg (or Rimactazid-300 two
tablets) at a time daily.
Retreatmentpatients:
Body weight < 50kg, initial 2 months- Rimstar
4-FDC 3 tablets at a time daily, &
Streptomycin 15mg/kg daily; next 1 monthRimstar
4-FDC 3 tablets at a time daily; next
5 months- continuation dose Rifampicin
450mg + Isoniazid 300mg (or Rimactazid-450
one tablet) daily, & Ethambutol 400mg 2
tablets (800mg) at a time daily.
Body weight > 50kg, initial 2 months- Rimstar
4-FDC 4 tablets at a time daily, &
Streptomycin 15mg/kg daily; next 1 monthRimstar
4-FDC 4 tablets at a time daily; next
5 months- continuation dose Rifampicin
600mg + Isoniazid 300mg (or Rimactazid-300
two tablets) at a time daily, & Ethambutol
400mg 21/2 tablets (lOOOmg) at a time daily.
Rimstar 4-FDC x 50's pack: 600.00 MRP