Amitriptyline + Chlordiazepoxide

This is indicated for the treatment of patients with moderate to severe depression associated with moderate to severe anxiety. The therapeutic response to this combination occurs earlier and with fewer treatment failures than when either amitriptyline or chlordiazepoxide is used alone. Symptoms likely to respond in the first week of treatment include: insomnia, feelings of guilt or worthlessness, agitation, psychic and somatic anxiety, suicidal ideation and anorexia.

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